Publications

Journal Articles

Harrison RG, Gordon N, McGuire K, Wallentine S, Mohl G, Lynch J, Busath D. 2017. Divalent copper complexes as influenza A inhibitors. Antiviral Research. 100-106.

Gleed ML, Ioannidis H, Kolocouris A, Busath DD. 2015. Resistance-Mutation (N31) Effects on Drug Orientation and Channel Hydration in Amantadine-Bound Influenza A M2. Journal of Physical Chemistry B. 119:11548-11559.  doi:10.1021/acs.jpcb.5b05808

Durrant MG, Eggett DL, Busath DD. 2015. Investigation of a recent rise of dual amantadineresistance mutations in the influenza A M2 sequence. BMC Genetics. 16(Suppl 2):S3.  doi:10.1186/1471-2156-16-S2-S3

Gleed ML, Busath DD. 2014. Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N). Journal of Physical Chemistry B. 119(3):1225-1231.  doi:dx.doi.org/10/1021/jp508545d

Kolocouris A, Tzitzoglaki C, Johnson B, Zell R, Wright A, Cross TA, Tietjen I, Fedida D, Busath DD. 2014. Adamantanes with persistent in vitro efficacy against H1N1 (2009) Influenza A. Journal of Medicinal Chemistry. 57:4629-4639.

Cross TA, Dong H, Sharma M, Busath DD, Zhou H. 2012. M2 Protein from Influenza A: From multiple structures to biophysical and functional insights. Current Opinions Virology. 2:128-133.

Nelson SC, Neely SK, Melonakos ED, Bell JD, Busath DD. 2012. Fluorescence anisotropy of diphenylhexatriene and its cationic trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: Opposing responses to isoflurane. BMC Biophysics. 5:5.

Mellor BL, Khadka S, Busath DD, Mazzeo BA. 2011. Influence of pKa shifts on the calculated dipole moments of proteins. The Protein Journal. 30:490-498.

Separovic F, Killian JA, Cotten M, Busath DD, Cross TA. 2011. Modeling the membrane environment for membrane proteins. Biophysical Journal. 100:2073-2074.

Sharma M, Li C, Busath DD, -X. Zhou H, Cross. TA. 2011. Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim. et Biophys. Acta., Biomembranes. 1808:516-521.

Peterson E, Ryser T, Funk S, Inouye D, Sharma M, Qin H, Cross TA, Busath DD. 2011. Functional reconstitution of influenza A M2(22-62). 1808:516-521.

Mellor BL, Cruz Cortes E, Busath DD, Mazzeo BA. 2011. Method for Estimating the Internal Permittivity of Proteins Using Dielectric Spectroscopy. Journal of Physical Chemistry B. 115(10):2205-2213.

Sharma M, Yi M, Hao D, Qin H, Peterson E, Busath DD, Zhou H, Cross TA. 2010. Insights into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science. 330:509-512.

Jones TL, Fu R, Nielson F, Cross TA, Busath DD. 2010. Gramicidin channels are internally gated. Biophysical Journal. 98:1486-1493.

Mustafa MA, Henderson D, Busath DD. 2009. Free-energy profiles for ions in the influenza M2-TMD channel. Proteins. 76:794-807.

Mustafa M, Henderson D, Busath DD. 2009. Computational studies of gramicidin permeation: An entryway sulfonate enhances cation occupancy at entry sites.. Biochim. Biophys. Acta. 1788:1404-1412.

Spohr E, Sovyak E, Trokhymchuk A, Busath DD. 2009. Electrostatic control of occupancy and valence selectivity in a charged nanometer-sized cylindrical pore. Materialwissenschaft und Werkstofftechnik. 40:247-254.

Miller CE, Busath DD, Strongin B, Majewski J. 2008. Integration of Ganglioside GT1b Receptor into DPPE and DPPC Phospholipid Monolayers: An X-ray Reflectivity and Grazing Incidence Diffraction Study. Biophysical Journal. 95:3278-3286.

Moffat JC, Vijayvergiya V, Gao PF, Cross TA, Woodbury DJ, Busath DD. 2008. Proton transport through influenza A virus M2 protein reconstituted in vesicles. Biophysical Journal. 94:434-445.

Durrant JD, Caywood D, Busath DD. 2006. Tryptophan contributions to the empirical free-energy profile in gramicidin A/M heterodimer channels. Biophysical Journal. 91:3230-3241.

Other

Busath DD, Woodbury DJ, Frost A. 2012. Endosis and exosis: New names for fusion and budding..

Presentations

Busath DD, Mohl GA. In Silico Discovery of a Protein-Protein Interaction Inhibitor for Influenza Viruses. 30th International Conference on Antiviral Research. Atlanta, GA. 2017 .

Busath DD, Mohl GA. In Silico Discovery of a Protein-Protein Interaction Inhibitor for Influenza Viruses. 61st Biophysical Society Meeting. New Orleans, LA. 2017 .

Busath DD, McGuire K. INFLUENZA A M2 S31N CONDUCTANCE IS BLOCKABLE, COMPLETELY BY AMANTADINE AND PARTIALLY BY RIMANTADINE. 61st Biophysical Society Meeting. New Orleans, LA. 2017 .

McGuire KL, Wallentine SK, Nathan GA, Mohl GA, Jensen MD, Harrison RG, Busath DD. Divalent Copper Complexes as Influenza a M2 S31N Blockers. 60th Biophysical Society Meeting. Los Angeles, CA. 2016 .

McGuire KL, Gleed ML, Busath DD. Observation of Partial and Complete Block by Amantadine and Rimantadine in Influenza A M2 S31N by Electrophysiology Methods. 60th Biophysical Society Meeting. Los Angeles, CA. 2016 .

Bodily TA, Peacock JB, Busath DD. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Utah Conference for Undergraduate Education. BYU. 2016 .

Mohl GA, Jensen MD, Wallentine SK, McGuire KL, Harrison RG, Busath DD. Preparing for the Emergence of a Highly Pathogenic Influenza Pandemic. Utah Conference for Undergraduate Education. University of Utah. 2016 .

Bodily TA, Peacock JB, Busath DD. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Neuroscience Poster Showcase. BYU. 2015 .

Bodily TA, Peacock JB, Busath DD. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Snowbird Neuroscience Symposium. Snowbird, UT. 2015 .

Bodily TA, Peacock JB, Busath DD. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Society for Neuroscience Meeting. Chicago, IL. 2015 .

Larsen J, Grooms M, Ashton BG, Busath DD. HOW NSAIDS AFFECT LIPID MONOLAYER AND BILAYER PROPERTIES. Biophysical Society 59th Annual Meeting. Baltimore, MD. 2015 .

Tietjen I, Miller SC, Boycott HE, Eldstrom J, Kwan DC, Chou D, Jalily P, Menconda D, Johnson FB, Schmidtke M, et al. Discovery of novel acylguanidine-based small molecules that block Influenza A M2 ion channel activity and drug-resistant virus. International Conference on Antiviral Research. Raleigh, NC. 2014 .

Kolocouris A, Johnson FB, Zell R, Schmidtke M, Sureda FX, Cross TA, Fedida D, Tzitzoglaki C, Ioannidis H, Hoffman A, et al. INFLUENZA A BLOCKERS WITH REDUCED RESISTANCE FORMATION. Biophysical Society 58th Annual Meeting. San Francisco, CA. 2014 .

Busath DD. Persistent Blockers for Modern Influenza A. PDBio Seminar. Provo. 2013 .

Kolocouris A, Johnson FB, Zell R, Wright AK, Tzitzoglaki C, Ioannidis H, Schmidtke M, López-Querol M, Cross TA, Childs R, et al. AMANTADINE ANALOGS THAT INHIBIT MDCK CELL INFECTION BY H1N1 2009 INFLUENZA A CONTAINING M2(S31N). Ion Channel Retreat 2013. Vancouver, CA. 2013 .

Kolocouris A, Johnson FB, Tzitzoglaki C, Sureda FX, Anderson T, Wright AK, Cross TA, Busath DD. Amantadine Analogs that Inhibit MDCK Cell Infection by H1N1 2009 Influenza A Containing M2(S31N). International Conference on Antiviral Research. San Francisco, CA. 2013 .

Kolocouris A, Johnson FB, Tzitzoglaki C, Sureda FX, Anderson T, Wright AK, Cross TA, Busath DD. Amantadine Analogs that Inhibit MDCK Cell Infection by H1N1 2009 Influenza A Containing M2(S31N). William DeGrado Lab Meeting. San Francisco, CA. 2013 .

Kolocouris A, Johnson B, Tzitzoglaki C, Gay NC, Busath DD. AMANTADINE ANALOGS THAT INHIBIT MDCK CELL INFECTION BY INFLUENZA A WITH M2(S31N). Biophysical Society 57th Annual Meeting. Philadelphia, PA. 2013 .

Fowler MR, Busath DD. SIMULATIONS OF THE PHASE TRANSITION OF DPPC BILAYER WITH AND WITHOUT DPH OR TMA-DPH USING CHARMM36. Biophysical Society 57th Annual Meeting. Philadelphia, PA. 2013 .

Busath DD. Can we Stop Pandemic Flu with an Anti-viral Drug?. Current Topics in Molecular Life Sciences Seminar. Provo, UT. 2011 .

Busath DD. Influenza A M2 is a Drug Target. Ion Channel Workshop. Vancouver, BC, Canada. 2011 .

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